Study of the gag-coded polyproteins of type D retroviruses Block of glycosylation inhibits the processing of major structural protein

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Abstract
The study of the gag-coded glycosylated polyprotein (gPr78gag) from type D retrovirus-producing cells is reported. It is shown that glycosylation inhibitors tunicamycin and 2-deoxy-D-glucose are blocking the synthesis of gPr78gag. This demonstrates that gPr78gag is a N-glycan. The protein part of gPr78gag is supposedly identified (MW=65 k). The inhibitors used partially stopped the processing of gag-coded polyprotein Pr78gag into core protein p27 as shown in pulse-chase experiments.