The ultrastructure of cholesterol granuloma of the middle ear: an electron microscope study

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Abstract
The ultrastructure of giant cells in human cholesterol granuloma and their role in the absorption of cholesterol needles are studied. Cholesterol is a highly resistant substance in its crystalline form. The giant cells have endoplasmic structures and organelles, and are partially crowded with lysosomes as evidence of their active role in the absorption and removal of cholesterol formed in the granuloma from blood, mucus or necrotic material.