Orosomucoid and Haptoglobin Excretion in Rat Glomerulonephritis and Tubulonephritis

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Abstract
Haptoglobin and orosomucoid were detected and measured in concentrated normal rat urine by radial immunodiffusion. Normal haptoglobin clearance was 33 nl/min (190 nl/ min/kg) and normal orosomucoid clearance 146 nl/min (840 nl/ min/kg). During nephrotoxic serum glomerulonephritis both glycoproteins increased considerably in urine in two phases; in serum, after an early peak, haptoglobin returned to the normal level and orosomucoid fell below the normal value. During mercuric chloride tubulonephritis, an early sharp peak of both glycoproteins was observed chiefly in urine but also in serum.

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