Inhibition of histidine decarboxylase. Derivatives of histidine
- 1 April 1977
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 20 (4) , 506-509
- https://doi.org/10.1021/jm00214a009
Abstract
Histidine derivatives [28] were tested as inhibitors of histidine decarboxylase from rat stomach. Potent inhibition was observed with the methyl ester of L-histidine (1) which had a Ki = 1.8 .times. 10-6 M. Substitution on 1 at various positions resulted in a decrease or complete loss of inhibition. Substituent requirements for inhibition of histidine decarboxylase are discussed. A simple disposable apparatus for the radiometric assay of histidine decarboxylase is described.This publication has 5 references indexed in Scilit:
- RECEPTORS MEDIATING SOME ACTIONS OF HISTAMINEBritish Journal of Pharmacology and Chemotherapy, 1966
- Histidine decarboxylase in the fetal ratBiochemical Pharmacology, 1963
- Determination of histidine decarboxylase activity by liquid scintillation counting of C14O2Analytical Biochemistry, 1963
- AROMATIC L-AMINO ACID DECARBOXYLASE1962
- On the Preparation and Properties of Some Amino Acid Amides1Journal of the American Chemical Society, 1955