RESPIRATORY TRACT INVOLVEMENT IN CYSTIC FIBROSIS OF PANCREAS (MUCOVISCIDOSIS)
- 6 December 1952
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA
- Vol. 150 (14) , 1407
- https://doi.org/10.1001/jama.1952.03680140045014
Abstract
Respiratory tract involvement has been recognized as part of the clinical picture of cystic fibrosis of the pancreas since it was first described by Passini in 1919. Andersen, in 1938, correlated the pancreatic changes with the development of steatorrhea and pneumonia and established cystic fibrosis of the pancreas as a clinical entity.1Evidence of vitamin A deficiency in many of the patients in Andersen's series suggested that the pulmonary infection might be secondary to vitamin A deficiency, induced by lowered absorption due to the pathological state of the pancreas. This view led to treatment based principally on nutritional measures. Little or no attempt was directed to control of the pulmonary symptoms. A series of uninterrupted studies over the past 15 years at the Boston Children's Hospital, calling into play a number of such diverse disciplines as pathology, chemistry, bacteriology, nutrition, pulmonary and cardiac physiology, and genetics have demonstrated thatKeywords
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