DISTRIBUTION OF NATURAL LETHAL GENES ON THE SECOND CHROMOSOME OF DROSOPHILA MELANOGASTER

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Abstract
By using 3 dominant marker genes (Sp, Bl, L), 76 loci of recessive lethal genes were determined on the 2nd chromosome, isolated from natural populations of Drosophlla meianogaster. The 76 natural lethal loci were not distributed randomly along the genetic map; 19 loci being in the left (from 0 to 40 units), 38 loci in the middle (40-70) and 19 loci in the right (70-108) region. The distribution of 26 loci of the spontaneous lethal genes obtained in the course of experiments was apparently at random; 8 loci being in the left, 7 loci in the middle, and 11 loci in the right region. The apparent non-random distribution of the natural lethal genes was difficult to determine in view of the location of most persistent lethal genes near the centromeres. Six 2nd-chromosome inversions were found to be associated with the natural lethals. No inversion could be detected in association with the spontaneous lethals.