'On‐off' phenomenon in Parkinson's disease
- 1 August 1988
- journal article
- research article
- Published by Wolters Kluwer Health in Neurology
- Vol. 38 (8) , 1245
- https://doi.org/10.1212/wnl.38.8.1245
Abstract
Administration of a low-protein diet to parkinsonian patients with “on-off” syndromes consistently increased the total daily time of “on” states when compared with a high-protein diet. The clinical effect of the low-protein diet may be due to a marked decrease in the plasma concentration of large neutral amino acids that compete with L-dopa for carrier-mediated transport into the brain.This publication has 1 reference indexed in Scilit:
- GABA receptor binding in the parkinsonian brainLife Sciences, 1978