Sweet's Syndrome

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Abstract
IN 1964 Sweet described a distinctive dermatologic disease with systemic manifestations that he called acute febrile neutrophilic dermatosis. The skin condition consists of painful, raised plaques, nodules, and pustules that histologically show a perivascular neutrophilic infiltrate in the dermis. The eruption occurs acutely or episodically and is almost always accompanied by fever and neutrophilic leukocytosis. Antibiotics are ineffective, but corticosteroids result in prompt resolution without scarring. Eight previously reported1-5cases described patients with Sweet's syndrome who experienced acute leukemia during the course of their illness. We report two other cases of Sweet's syndrome in which leukemia developed and emphasize that this dermatosis appears to be associated with hematologic malignant conditions. Report of Cases Case 1.— A 45-year-old woman was hospitalized in March 1977 after having had development of painful skin eruptions over the face, neck, chest, and extremities (and similar painful lesions in the mouth) during a three-week period,

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