An Optical Biosensor for Rapid and Label-Free Detection of Cells
- 1 March 2006
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 128 (12) , 3862-3863
- https://doi.org/10.1021/ja057490l
Abstract
We report a broadly applicable optical method for rapid and label-free detection of as few as 45 cells. In this method, bacterial cells are detected by measuring the amount of laser light transmitted through a small glass well functionalized with antibodies which specifically recognize and capture the cells. The described approach is simple, rapid, economical, and promising for portable and high-throughput detection of a wide variety of pathogenic and infectious cells.Keywords
This publication has 19 references indexed in Scilit:
- Gold Glyconanoparticles as Probes to Explore the Carbohydrate‐Mediated Self‐Recognition of Marine Sponge CellsChemBioChem, 2005
- Rapid detection of viruses using electrical biochips and anti-virion seraLetters in Applied Microbiology, 2005
- The Use of Carbohydrate Microarrays to Study Carbohydrate-Cell Interactions and to Detect PathogensChemistry & Biology, 2004
- A rapid bioassay for single bacterial cell quantitation using bioconjugated nanoparticlesProceedings of the National Academy of Sciences, 2004
- Electrical detection of single virusesProceedings of the National Academy of Sciences, 2004
- Intact cell adhesion to glycan microarraysGlycobiology, 2003
- Cell detection based on protein array using modified glass slidesElectrophoresis, 2003
- A B Cell-Based Sensor for Rapid Identification of PathogensScience, 2003
- Surface sensing and adhesion of Escherichia coli controlled by the Cpx-signaling pathwayProceedings of the National Academy of Sciences, 2002
- PCR Detection of Bacteria in Seven MinutesScience, 1999