SERUM CREATININE - CAP SURVEY

  • 1 January 1978
    • journal article
    • research article
    • Vol. 70  (3) , 503-507
Abstract
The results of the 1976-1977 College of American Pathologists Survey of [human] serum creatinine measurements performed by more than 5000 laboratories are presented. The most widely used method employs the colorimetric measurement of the alkaline picrate-creatinine (Jaffe) reaction. In general, all manual and automated systems yielded comparable creatinine concentrations except the centrifugal analyzers, which manifested a consistently high bias. Interlaboratory variation was lowest for continuous-flow and the DuPont discrete systems. Lloyd''s reagent resulted in a clinically insignificant reduction of creatinine concentration in lyophilized sera.

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