The acetylenic monoamine oxidase inhibitors clorgyline, deprenyl, pargyline and J-508: their properties and applications

1 September 1981

journal article
research article
Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology

Vol. 33 (1) , 341-347
https://doi.org/10.1111/j.2042-7158.1981.tb13800.x

Abstract

The article presents a short review of some of the properties of the acetylenic inhibitors of monoamine oxidase currently under investigation: clorgyline, (—)-deprenyl, pargyline and J-508. Their substrate-selective inactivation, mechanism of inhibition, titration and pharmacology with respect to monoamine oxidase are critically discussed.

Keywords

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