HEMODYNAMIC EFFECTS OF SUBLINGUAL NIFEDIPINE IN CONGESTIVE HEART FAILURE

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Abstract
Hemodynamic response of nifedipine in 11 patients with congestive heart failure was examined. At 30 min after sublingual administration of nifedipine, CI [cardiac index] and SVI [stroke volume index] were increased together with a decrease in PAEDP [pulmonary arterial end diastolic pressure] and TSVRI [total systemic vascular resistance index]. The increase in CI was proportional to the decrease in TSVRI. At 24 h after continuous administration of nifedipine, 6 of 11 patients did not show the improvement of left ventricular function. Sublingual administration of nifedipine is effective in the short-term therapy of the patients with a markedly decreased cardiac output and an increased systemic vascular resistence.