Duplication followed by deletion accounts for the structure of an Indian deletion βo-thalassemia gene
Open Access
- 1 January 1982
- journal article
- Published by Oxford University Press (OUP) in Nucleic Acids Research
- Vol. 10 (24) , 8025-8029
- https://doi.org/10.1093/nar/10.24.8025
Abstract
Nucleotide sequence analysis of a cloned deletion β-globin gene from a patient with βo-thulassemia demonstrates a 619 nucleotide deletion extending from the 3′ third of the second intervening sequence through 209 bases of 3′ flanking DNA. However, an additional novel heptanucleotide was identified between the deletion endpoints, suggesting a complex etiology for this rearrangement.Keywords
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