Spatial and temporal disease progression of adult-onset subacute sclerosing panencephalitis
- 28 May 2002
- journal article
- case report
- Published by Wolters Kluwer Health in Neurology
- Vol. 58 (10) , 1568-1571
- https://doi.org/10.1212/wnl.58.10.1568
Abstract
An adult-onset case of subacute sclerosing panencephalitis with occipitofrontal spread of the infection documented clinically and by MRI is reported. Autopsy revealed numerous intranuclear viral inclusions and widespread demyelination in both frontal lobes. In the occipital lobes where the disease started 5 years previously, inclusions were rare, but degenerative tissue changes were prominent. This case underlines the importance of measles virus migration for the progression of this fatal disorder.Keywords
This publication has 8 references indexed in Scilit:
- Spread of measles virus through axonal pathways into limbic structures in the brain of TAP1 ‐/‐ miceJournal of Medical Virology, 1997
- Adult‐onset subacute sclerosing panencephalitis: Case reports and review of the literatureMovement Disorders, 1997
- MRI findings in subacute sclerosing panencephalitisNeurology, 1996
- The Significance of Measles Virus Antigen and Genome Distribution in the CNS in SSPE for Mechanisms of Viral Spread and DemyelinationJournal of Neuropathology and Experimental Neurology, 1996
- The prognosis of subacute sclerosing panencephalitis in adultClinical Neurology and Neurosurgery, 1991
- Signs of focal posterior cerebral abnormality in early subacute sclerosing panencephalitisAnnals of Neurology, 1986
- Subacute sclerosing panencephalitisNeurology, 1974
- Adult Onset of Subacute Sclerosing PanencephalitisArchives of Neurology, 1973