Basic Biological Sciences

Abstract
Searching for an experimental model simulating the root canal, a two-stage procedure was evolved using polyethylene tubes implanted subcutaneously in rabbits. The reaction to the model was histologically evaluated, and the rate of release of macromolecules from the tubes was studied using radio-labeled endotoxin and albumin. The model proved suitable for evaluating an animal's tissue response to the slow and prolonged influx of foreign fluids.

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