Characterization of tumor cell lines derived from murine gammaherpesvirus-68-infected mice
- 1 September 1996
- journal article
- research article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 70 (9) , 6516-6518
- https://doi.org/10.1128/jvi.70.9.6516-6518.1996
Abstract
Cell lines were derived from mice with murine gammaherpesvirus-68 (MHV-68)-associated lymphoproliferative disease. Four were of an ambiguous phenotype and were MHV-68 negative. One, S11, was a B lymphocyte that contained MHV-68 genomes in both linear and episomal forms and released virus. The line was clonable and grew into tumors in nude mice. This is the first naturally occurring MHV-68-positive B-cell line to be generated, and it will be an invaluable tool for the study of MHV-68 latency.Keywords
This publication has 19 references indexed in Scilit:
- Murine gammaherpesvirus-induced splenomegaly: a critical role for CD4 T cellsJournal of General Virology, 1996
- Synthesis and Anti-Herpes Virus Activity of 2‘-Deoxy-4‘-thiopyrimidine NucleosidesJournal of Medicinal Chemistry, 1996
- Identification of Herpesvirus-Like DNA Sequences in AIDS-Sssociated Kaposi's SarcomaScience, 1994
- Murine gammaherpesvirus 68 establishes a latent infection in mouse B lymphocytes in vivoJournal of General Virology, 1992
- Competitive PCRNature, 1992
- Virological and pathological features of mice infected with murine gammaherpesvirus 68Journal of General Virology, 1992
- T-cell control of Epstein–Barr virus-infected B cells is lost during P. falciparum malariaNature, 1984
- Persisting oncogenic herpesvirus induced by the tumour promoter TPANature, 1978
- A Children's Cancer Dependent on Climatic FactorsNature, 1962
- A sarcoma involving the jaws in african childrenBritish Journal of Surgery, 1958