Effect of butylated hydroxytoluene and butylated hydroxyanisole on the mutagenicity of 3,2´‐dimethyl‐4‐aminobiphenyl
- 1 January 1983
- journal article
- Published by Taylor & Francis in Nutrition and Cancer
- Vol. 5 (3-4) , 153-158
- https://doi.org/10.1080/01635588309513792
Abstract
This study was undertaken to investigate the possible antimutagenic effects of butylated hydroxyanisole (BHA) and butylated hydroxytoluene (BHT) on 3,2'-dimethyl-4-aminobiphenyl (DMAB)-induced mutagenicity, using the Ames Salmonella/mammalian microsome system. The addition of 100-250 micrograms of BHT or 25-500 micrograms of BHA/plate was found to inhibit DMAB-induced mutagenicity in Salmonella strains TA 98 and TA 100. In TA 100, the mutagenicity was further inhibited with the addition of S9 prepared from the livers of rats fed a 0.6% BHT diet as compared to S9 from the animals fed a diet containing no BHT.Keywords
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