Bioprocess development for the cultivation of human T-lymphocytes in a clinical scale
- 1 January 2002
- journal article
- Published by Springer Nature in Cytotechnology
- Vol. 38 (1/3) , 135-145
- https://doi.org/10.1023/a:1021174619613
Abstract
Adoptive transfer of large numbers of donor-derived T-lymphocytesmay offer a promising treatment of a variety of viral and malignant diseases. The key step in this approach is the ex vivogeneration...Keywords
This publication has 22 references indexed in Scilit:
- The Lactate Issue Revisited: Novel Feeding Protocols To Examine Inhibition of Cell Proliferation and Glucose Metabolism in Hematopoietic Cell CulturesBiotechnology Progress, 2000
- The use of Teflon cell culture bags to expand functionally active CD8+ cytotoxic T lymphocytesJournal of Immunological Methods, 1999
- Activated Long-Term Peripheral Blood Cultures as Preparation for Adoptive Alloreactive Cell Therapy in Cancer PatientsJournal of Hematotherapy, 1997
- Differential in vitro effects of physiological and atmospheric oxygen tension on normal human peripheral blood mononuclear cell proliferation, cytokine and immunoglobulin productionInternational Journal of Immunopharmacology, 1996
- Analysis and sorting of live cells according to secreted molecules, relocated to a cell-surface affinity matrix.Proceedings of the National Academy of Sciences, 1995
- A feasible method for expansion of peripheral blood lymphocytes by culture with immobilized anti-CD3 monoclonal antibody and interleukin-2 for use in adoptive immunotherapy of cancer patientsBiomedicine & Pharmacotherapy, 1993
- Optimization of culture conditions for activation and large‐scale expansion of human T lymphocytes for bispecific antibody‐directed cellular immunotherapyInternational Journal of Cancer, 1992
- The use of anti-CD3 and anti-CD28 monoclonal antibodies to clone and expand human antigen-specific T cellsJournal of Immunological Methods, 1990
- Culture of human tumor infiltrating lymphocytes in hollow fiber bioreactorsJournal of Immunological Methods, 1990
- A New Approach to the Adoptive Immunotherapy of Cancer with Tumor-Infiltrating LymphocytesScience, 1986