THE EFFECT OF CYSTEINE ON STREPTOMYCIN AND STREPTOTHRICIN

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Abstract
Streptomycin (SM) was inactivated by cysteine; streptothrycin (ST) was not. A CCl4 soln. of I2 reversed the inhibition when added to SM solns. containing cysteine and shaken thoroughly. SM was also inhibited by 2-amino-ethanethiol but hardly by thioglycollic acid. Inhibition expts. were done by adding neutral solns. of the organic S compds. to SM or ST dissolved in neutral phosphate buffer. After several hrs. the solns. were tested against Bacillus subtilis by the Oxford cup method.

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