Esophageal ulcers associated with tetracycline therapy

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Abstract
Esophageal ulceration has rarely been reported secondary to medicinal agents. Three patients with esophageal ulceration associated with the ingestion of tetracycline or its derivative doxycycline were treated. In light of the strong temporal relationship between taking the capsules and the onset of the esophageal ulceration, the capsules probably were the cause of the ulcers. An alternative agent to tetracycline or doxycycline is recommended, if possible, for patients with any esophageal obstructive element. Patients should be cautioned not to take these drugs within 1 h of going to bed.

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