COMPARATIVE EVALUATION OF CARPROFEN AND INDOMETHACIN IN RHEUMATOID PATIENTS

  • 1 January 1980
    • journal article
    • research article
    • Vol. 18  (11) , 482-487
Abstract
Patients (36) with definite or classical rheumatoid arthritis were studied in a 6-wk double-blind parallel trial. They were randomly divided into 3 groups and received carprofen (6-chloro-.alpha.-methylcarbazole-2-acetic acid) stepwise 150, 200 and 250 mg/day, carprofen 350, 400 and 450 mg/day or indomethacin 100 mg/day. Classical methods and parameters for evaluating the disease activity of rheumatoid arthritis were used. A large panel of laboratory tests were involved in the assessment of toxicity. The incidence of adverse effects was similar for both drugs, cutaneous and gastrointestinal symptoms were more frequent with carprofen than with indomethacin, but CNS reactions were elicited more often with indomethacin. For most of the efficacy variables studied, the carprofen high dosage regimen at 5 and 6 wk was statistically superior or at least not different from the indomethacin group; both of these were superior to the carprofen low dosage regimen.

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