EFFECT OF COMPLEMENT DEPLETION ON BACTERIAL LIPOPOLYSACCHARIDE (LPS)-INDUCED HEMODYNAMIC AND HEMATOLOGIC CHANGES IN RHESUS-MONKEY

  • 1 January 1978
    • journal article
    • research article
    • Vol. 92  (1) , 227-240
Abstract
LPS isolated from Salmonella minnesota R595 or from Escherichia coli 0111:B4 induced hypotension in rhesus monkeys with normal complement [c] levels. This hypotension was accompanied by decreased total peripheral resistance. The depletion of C3 and terminal C components by prior i.p. administration of the anticomplementary protein cobra factor did not alter the hemodynamic changes which occur following the rapid injection of 5 mg/kg of R595 LPS, the infusion of 500 .mu.g/kg of R595 LPS or the injection of 500 .mu.g/kg of 0111:B4 LPS. The LPS-induced hemodynamic changes in the subhuman primate are probably mediated by pathways which do not require the participation of C3. The kinetics and extent of the neutropenia and thrombocytopenia resulting from the injection of 0111:B4 or R595 LPS were not altered by prior depletion of greater than 95% of the plasma C3.