Double‐blind trial of pergolide for Parkinson's disease

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Abstract
Pergolide mesylate, a dopamine agonist, was studied as adjunctive therapy in a 6-mo. double-blind trial in 20 patients with Parkinson''s disease who were achieving less than optimal response from Sinemet. As pergolide or placebo was administered in increasing dosage. Sinemet was reduced if side effects developed. Both the pergolide and placebo groups improved significantly (P < 0.05). The pergolide group improved 30% at the end of 24 wk and the placebo group 23%. There was no significant difference between drug and placebo groups, possibly due to a fortuitous support group and the side effects that may have burdened the pergolide group. Pergolide had a definite antiparkinsonian effect.