Endogenous brain IL-1 mediates LPS-induced anorexia and hypothalamic cytokine expression
- 1 July 2000
- journal article
- research article
- Published by American Physiological Society in American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
- Vol. 279 (1) , R93-R98
- https://doi.org/10.1152/ajpregu.2000.279.1.r93
Abstract
The present study was designed to determine the role of endogenous brain interleukin (IL)-1 in the anorexic response to lipopolysaccharide (LPS). Intraperitoneal administration of LPS (5–10 μg/mouse) induced a dramatic, but transient, decrease in food intake, associated with an enhanced expression of proinflammatory cytokine mRNA (IL-1β, IL-6, and tumor necrosis factor-α) in the hypothalamus. This dose of LPS also increased plasma levels of IL-1β. Intracerebroventricular pretreatment with IL-1 receptor antagonist (4 μg/mouse) attenuated LPS-induced depression of food intake and totally blocked the LPS-induced enhanced expression of proinflammatory cytokine mRNA measured in the hypothalamus 1 h after treatment. In contrast, LPS-induced increases in plasma levels of IL-1β were not altered. These findings indicate that endogenous brain IL-1 plays a pivotal role in the development of the hypothalamic cytokine response to a systemic inflammatory stimulus.Keywords
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