The Effect of Arsenates on the Storage of Lead

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Abstract
A soluble arsenate, such as Na arsenate, when fed to rats receiving Pb carbonate, was shown to produce effects similar to those produced by Pb arsenate alone. The adm. of Na arsenate with Pb carbonate diminished the concentration of Pb in the kidneys, while the conc. of arsenic amounted to only half that of the Na arsenate group. More significant is the fact that arsenates in general definitely diminish the storage of Pb in bone tissue. The amount of pathologic damage follows that observed in expts. previously described in which Pb arsenate and Pb carbonate were fed to animals for comparison of the relative toxicity of molecular components. In this study the spleen showed the most marked changes with Na arsenate and the least with Pb carbonate. The tissues from the animals receiving both Na arsenate and Pb carbonate showed changes of an intermediate degree. No pathologic changes of any significance were observed in the liver.