Evasion of innate immunity by vaccinia virus
- 1 March 2005
- journal article
- review article
- Published by Cambridge University Press (CUP) in Parasitology
- Vol. 130 (S1) , S11-S25
- https://doi.org/10.1017/s0031182005008127
Abstract
Vaccinia virus, a member of the Poxviridae, expresses many proteins involved in immune evasion. In this review, we present a brief characterisation of the virus and its effects on host cells and discuss representative secreted and intracellular proteins expressed by vaccinia virus that are involved in modulation of innate immunity. These proteins target different aspects of the innate response by binding cytokines and interferons, inhibiting cytokine synthesis, opposing apoptosis or interfering with different signalling pathways, including those triggered by interferons and toll-like receptors.Keywords
This publication has 151 references indexed in Scilit:
- Toll-like receptor control of the adaptive immune responsesNature Immunology, 2004
- Activation of the IκB Kinase Complex by TRAF6 Requires a Dimeric Ubiquitin-Conjugating Enzyme Complex and a Unique Polyubiquitin ChainPublished by Elsevier ,2000
- Programmed Cell Death in Animal DevelopmentCell, 1997
- Actin-based motility of vaccinia virusNature, 1995
- Interleukin‐1‐induced activation of a protein kinase co‐precipitating with the type I interleukin‐1 receptor in T cellsEuropean Journal of Immunology, 1994
- Ribosomal protein S2/Sa kinase purified from HeLa cells infected with vaccinia virus corresponds to the B1R protein kinase and phosphorylates in vitro the viral ssDNA-binding proteinJournal of General Virology, 1994
- A novel heterodimeric cysteine protease is required for interleukin-1βprocessing in monocytesNature, 1992
- Modulation of MHC antigen expression by viruses and oncogenesImmunology Today, 1991
- Antiviral actions of interferon interferon-regulated cellular proteins and their surprisingly selective antiviral activitiesVirology, 1991
- T2 open reading frame from the shope fibroma virus encodes a soluble form of the TNF receptorBiochemical and Biophysical Research Communications, 1991