Comparative measurement of Regional blood flow, oxygen and glucose utilisation in soft tissue tumour of rabbit with positron imaging

Publisher Website
Google Scholar
Abstract
The C15O2 and 15O2 steady state techniques were used to quantitatively measure regional blood flow (RBF) and regional oxygen utilization (ROU) in a rabbit tumor model. RBF values of 4.6 .+-. 0.6 ml/min per 100 cm3 were measured for normal muscle tissue and 11.0 .+-. 3.0 ml/min per 100 cm3 for tumor surface. Corresponding values for ROU were 18.3 .+-. 3.5 .mu.mol/min per 100 cm3 for normal tissue and 39.7 .+-. 20.1 .mu.mol/min per 100 cm3 for tumor surface. 18F-2-fluoro-2-deoxy-D-glucose (2FDG) was used in the same tumor model to measure glucose metabolic rate. The values obtained were 4.3 .+-. 2.1 .mu.mol/min per 100 cm3 for normal muscle tissue and 53.8 .+-. 18.3 .mu.mol/min per 100 cm3 for tumor tissue. Tumor growth was followed with a series of measurements of blood flow, O2 and glucose metabolism at intervals of 1 wk. Tumor-to-muscle ratios increased more rapidly with time for 2FDG than for O2 utilization and blood flow. The effect of radiation on tumor and normal tissue was followed by measurements of RBF and ROU. RBF values increased both in tumor and normal muscle tissue during radiation and decreased during 1 wk after radiation. ROU-values decreased (30%) in tumor and increased (45%) in normal muscle tissue during radiation. Even at 1 wk after radiation, ROU-values were 30% lower in tumor and 45% higher in normal muscle tissue than before radiation.

This publication has 16 references indexed in Scilit: