SEVERE DEFICIENCY OF NATURAL-KILLER ACTIVITY IN THE PERIPHERAL-BLOOD OF PATIENTS WITH HAIRY-CELL LEUKEMIA

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  • 1 January 1983
    • journal article
    • research article
    • Vol. 61  (6) , 1132-1137
Abstract
Natural killer (NK) activity against K-562 tumor cells was evaluated in peripheral blood leukocytes (PBL) obtained from untreated patients affected by hairy cell leukemia (HCL). NK activity present in PBL from 10 HCL patients was at least 6-fold lower (P < 0.01) than that present in PBL from 15 healthy donors. Decreased NK activity HCL PBL was not due to dilution of the NK effector cells by the neoplastic cells; NK activity of PBL from 4 HCL patients with less than 5% circulating neoplastic cells was still 5-fold lower (P < 0.01) than that present in normal PBL. Partial characterization of the NK defect in HCL patients indicated that: defective cytotoxicity was not dependent on the duration of the assay; HCL PBL added to normal PBL during the assay did not exert suppressor activity; NK activity of HCL PBL could be potentiated in vitro by interferon; and low levels of NK activity were associated with reduced numbers of circulating monocytes (P < 0.01) and of large granular lymphocytes (LGL) (P < 0.01). The low levels of NK activity present in the peripheral blood of HCL patients may be related to reduced numbers of circulating effector cells.