N-(functionalized alkyl) derivatives of 6-aminopenicillanic acid: A new series of specific inhibitors of .BETA.-lactamase from Enterobacter cloacae P99.
- 1 January 1983
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 36 (11) , 1507-1515
- https://doi.org/10.7164/antibiotics.36.1507
Abstract
Of 9 new N-alkylaminopenicillanic acids prepared via efficient direct monoalkylation reactions, 8 were specific inhibitors of cephalosporinase P99 with 50% inhibitory concentrations .ltoreq. 4 mg/l. Representative corresponding S-oxidized derivatives were less active.This publication has 3 references indexed in Scilit:
- Interaction of azthreonam and related monobactams with beta-lactamases from gram-negative bacteriaAntimicrobial Agents and Chemotherapy, 1982
- Inactivation of the RTEM .beta.-lactamase from Escherichia coli. Interaction of penam sulfones with the enzymeBiochemistry, 1981
- 6-beta-bromopenicillanic acid, a potent beta-lactamase inhibitor.Proceedings of the National Academy of Sciences, 1978