Transforming properties of YAP , a candidate oncogene on the chromosome 11q22 amplicon
Top Cited Papers
- 15 August 2006
- journal article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 103 (33) , 12405-12410
- https://doi.org/10.1073/pnas.0605579103
Abstract
In a screen for gene copy-number changes in mouse mammary tumors, we identified a tumor with a small 350-kb amplicon from a region that is syntenic to a much larger locus amplified in human cancers at chromosome 11q22. The mouse amplicon contains only one known gene, Yap , encoding the mammalian ortholog of Drosophila Yorkie (Yki), a downstream effector of the Hippo(Hpo)–Salvador(Sav)–Warts(Wts) signaling cascade, recently identified in flies as a critical regulator of cellular proliferation and apoptosis. In nontransformed mammary epithelial cells, overexpression of human YAP induces epithelial-to-mesenchymal transition, suppression of apoptosis, growth factor-independent proliferation, and anchorage-independent growth in soft agar. Together, these observations point to a potential oncogenic role for YAP in 11q22-amplified human cancers, and they suggest that this highly conserved signaling pathway identified in Drosophila regulates both cellular proliferation and apoptosis in mammalian epithelial cells.Keywords
This publication has 54 references indexed in Scilit:
- Identification and Validation of Oncogenes in Liver Cancer Using an Integrative Oncogenomic ApproachCell, 2006
- The Hippo Signaling Pathway Coordinately Regulates Cell Proliferation and Apoptosis by Inactivating Yorkie, the Drosophila Homolog of YAPCell, 2005
- Control of Cell Proliferation and Apoptosis by Mob as Tumor Suppressor, MatsCell, 2005
- The Drosophila Ste20 family kinase dMST functions as a tumor suppressor by restricting cell proliferation and promoting apoptosisGenes & Development, 2003
- The Salvador partner Hippo promotes apoptosis and cell-cycle exit in DrosophilaNature Cell Biology, 2003
- Hippo promotes proliferation arrest and apoptosis in the Salvador/Warts pathwayNature Cell Biology, 2003
- The Drosophila Mst Ortholog, hippo, Restricts Growth and Cell Proliferation and Promotes ApoptosisCell, 2003
- hippo Encodes a Ste-20 Family Protein Kinase that Restricts Cell Proliferation and Promotes Apoptosis in Conjunction with salvador and wartsCell, 2003
- Shar-pei mediates cell proliferation arrest during imaginal disc growth inDrosophilaDevelopment, 2002
- salvador Promotes Both Cell Cycle Exit and Apoptosis in Drosophila and Is Mutated in Human Cancer Cell LinesCell, 2002