Mutation Induction in V79 Chinese Hamster Cells by Very Heavy Ions
- 1 January 1990
- journal article
- research article
- Published by Taylor & Francis in International Journal of Radiation Biology
- Vol. 58 (6) , 975-987
- https://doi.org/10.1080/09553009014552291
Abstract
Mutation induction (resistance to 6-thioguanine) in Chinese hamster fibroblasts (V79) by exposure to accelerated heavy ions (O, Ne, Ca, Ti, Ni, Xe, Pb and U with energies between 5 and 14.8 MeV/u) was investigated, covering a range of LET from 300 to about 15,700 KeV/.mu.m. The LET-dependence of the mutation induction cross-section (.sigma.m) has, in a similar way to inactivation (.sigma.i), to be described by separate curves for each ion. Both .sigma.m and mutagenicity (.sigma.m/.sigma.i) decrease with increasing specific energy for any given ion. Relative biological effectiveness for mutation induction was found to be significantly smaller than unity for the ions and energies investigated.This publication has 25 references indexed in Scilit:
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