SEQUENTIAL STUDIES ON THE PATHO-PHYSIOLOGY OF GLYCEROL-INDUCED ACUTE-RENAL-FAILURE

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  • 1 January 1980
    • journal article
    • research article
    • Vol. 96  (2) , 356-362
Abstract
The role of volume depletion and renal ischemia in the development of renal functional impairment in glycerol-induced ARF [acute renal failure] is not clear. This study was designed to evaluate the role of volume depletion in this model by determining the hemodynamic and functional alterations which occur in rats between 3-18 h after glycerol administration and the reversibility of these changes in response to Ringer loading. Three hours after glycerol, CIn [inulin clearance] and RBF [renal blood flow], measured by flowmeter, were reduced 70% and 52%, respectively, in comparison with control values. FeNa [fractional excretion of sodium] was 0.04%. Ringer loading increased CIn to 103% and RBF to 93% of control values. Qualitatively similar results were found 6 h after glycerol. At 18 h, CIn and RBF were 47% of control values. After Ringer loading, RBF rose to 100% of control. The response of CIn, was a function of the baseline FeNa. CIn increased substantially in rats with low FeNa but changed only slightly in animals in which this parameter was increased. The early reduction in the CIn is probably dependent upon the fall in RBF. At 12 and 18 h, the fall in CIn is not blood flow-dependent, and a second mechanism must be operative. FeNa seems to be a reliable index of the functional status of a given animal.