Asymmetric synthesis of functionalised pyrrolidines. Highly diastereoselective cyclisations mediated by sulfide and sulfoxide ligands
- 1 January 1992
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 4,p. 335-337
- https://doi.org/10.1039/c39920000335
Abstract
Silver(I)-catalysed cyclisation of sulfide 1b and sulfoxides 4 and 5 to give the corresponding 2-vinylpyrrolidines 2b, 6a and 7a, respectively proceeds with a high (up to 99% diastereoisomeric excess) level of diastereoselectivity; in all of these cases the sense of asymmetric induction observed has been shown to be the same.Keywords
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