α-Synuclein immunopositive Parkinson's disease-related inclusion bodies in lower brain stem nuclei
- 1 March 2001
- journal article
- research article
- Published by Springer Nature in Acta Neuropathologica
- Vol. 101 (3) , 195-201
- https://doi.org/10.1007/s004010000247
Abstract
Advanced silver stains and immunohistochemical reactions against α-synuclein were used to detect Parkinson's disease-related cytoskeletal abnormalities in select lower brain stem nuclei. Various types of inclusion bodies including inconspicuous and heretofore unnoted granular particles and thread-like Lewy neurites were visualized. Of the nuclei investigated (gigantocellular reticular nucleus, bulbar raphe nuclei, coeruleus-subcoeruleus area), only lipofuscin- or neuromelanin-laden neuronal types showed a propensity to develop the pathological changes. Neuronal types devoid of pigment deposits remained free of the cytoskeletal abnormalities. Fine, dust-like particles and small globular Lewy bodies were encountered solely within the limits of intraneuronal lipofuscin or neuromelanin deposits.Keywords
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