Activity of Retapamulin (SB-275833), a Novel Pleuromutilin, against Selected Resistant Gram-Positive Cocci
- 1 July 2006
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 50 (7) , 2583-2586
- https://doi.org/10.1128/aac.01432-05
Abstract
Retapamulin (SB-275833), the first pleuromutilin to be developed for human topical use, was tested against a selected population of staphylococci and beta-hemolytic streptococci. The MIC90 results for retapamulin were 0.12 microg/ml for Staphylococcus aureus and < or = 0.03 microg/ml for Streptococcus pyogenes; no cross-resistance was observed for organism subsets resistant to oxacillin, erythromycin, or mupirocin.Keywords
This publication has 11 references indexed in Scilit:
- Quality Control Guidelines for Susceptibility Testing of Retapamulin (SB-275833) by Reference and Standardized MethodsJournal of Clinical Microbiology, 2005
- Potency and spectrum of tigecycline tested against an international collection of bacterial pathogens associated with skin and soft tissue infections (2000–2004)Diagnostic Microbiology and Infectious Disease, 2005
- Mutations in ribosomal protein L3 and 23S ribosomal RNA at the peptidyl transferase centre are associated with reduced susceptibility to tiamulin in Brachyspira spp. isolatesMolecular Microbiology, 2004
- Inhibition of peptide bond formation by pleuromutilins: the structure of the 50S ribosomal subunit from Deinococcus radiodurans in complex with tiamulinMolecular Microbiology, 2004
- Emerging elevated mupirocin resistance rates among staphylococcal isolates in the SENTRY Antimicrobial Surveillance Program (2000): correlations of results from disk diffusion, Etest and reference dilution methodsDiagnostic Microbiology and Infectious Disease, 2002
- Tiamulin Activity against Fastidious and Nonfastidious Veterinary and Human Bacterial Isolates: Initial Development of In Vitro Susceptibility Test MethodsJournal of Clinical Microbiology, 2002
- Pleuromutilins. Part 1 The identification of novel mutilin 14-carbamatesBioorganic & Medicinal Chemistry, 2001
- Proposed quality control guidelines for National Committee for Clinical Laboratory Standards Susceptibility Tests using the veterinary antimicrobial agent tiamulinDiagnostic Microbiology and Infectious Disease, 2001
- Pleuromutilin antibioticsDrugs of the Future, 2000
- A Comparative Study with Two Administration Schedules of Leucovorin and 5-Fluorouracil in Advanced Colorectal CancerJournal of Chemotherapy, 1995