APOLIPOPROTEIN A-I AND B LEVELS IN ADOLESCENTS; A TRIAL TO DEFINE SUBJECTS AT RISK FOR CORONARY HEART DISEASE

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Abstract
The normal levels of apolipoprotein A-I and B (apo A-I, apo B) were determined in 220 male and 340 female 16- to 19-yr-old adolescents. In addition to these apolipoproteins, total and high density lipoprotein cholesterol (total-C HDL-C) were analyzed as an attempt to define subjects at higher risk for coronary heart disease (CHD). The normal levels were for boys: apo A-I 0.96 .+-. 0.13 g/l, apo B 0.64 .+-. 0.14 g/l; for girls: apo A-I 1.04 .+-. 0.18 g/l, apo B 0.65 .+-. 0.14 g/l; for girls taking combined oral contraceptives: apo A-I 1.14 .+-. 0.22 g/l, apo B 0.73 .+-. 0.16 g/l. Subjects with the following high-risk profiles were selected for further follow-up: Total-C and apo B .gtoreq. 95th percentile; Total-C or apo B .gtoreq. 95th and HDL-C or apo A-I .ltoreq. 5th percentile. Adolescents (7) had the combination of high total-C and apo B. None had any of the other combinations. One girl had lipid, apolipoprotein levels and a family history indicating familial hypercholesterolemia (f.h.). Another 2 adolescents were suspected of having f.h. while 1 girl might have abnormal levels secondary to oral combined contraceptives. Apparently, the analyses of apolipoproteins, especially apo B, are of value to trace adolescents at risk for future CHD.