Free D- and L-amino acids in ventricular cerebrospinal fluid from Alzheimer and normal subjects
- 1 September 1998
- journal article
- research article
- Published by Springer Nature in Amino Acids
- Vol. 15 (3) , 263-269
- https://doi.org/10.1007/bf01318865
Abstract
Free D-Ser, D-Asp and total D-amino acids were significantly higher (p < 0.05) in Alzheimer (AD) ventricular CSF than in normal CSF. There was no significant difference in the total L-amino acids between AD and normal CSF, but L-Gln and L-His were significantly higher (p < 0.05) in ADCSF. The higher concentrations of these D- and L-amino acids in AD ventricular CSF could reflect the degenerative process that occurs in Alzheimer's brain since ventricular CSF is the repository of amino acids from the brain.Keywords
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