The Nephrotic Syndrome as a Complication of Perchlorate Treatment of Thyrotoxicosis

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Abstract
PERCHLORATE is an inorganic monovalent anion that, like thiocyanate, is capable of inhibiting collection and interfering with retention of the iodide ion within the thyroid gland. Wyngaarden et al.,1 , 2 in 1952 and 1953, were the first to compare, in animals, the effects of perchlorate and other monovalent anions, and they found perchlorate to be ten times as potent as thiocyanate in discharging iodide previously collected by the thyroid gland. Perchlorate has been used widely in England and Europe generally in the treatment of hyperthyroidism, and has distinct advantages in that it is effective, inexpensive and relatively nontoxic.3 4 5 6 7 Godley and Stanbury . . .