Nonsteroidal anti-inflammatory drugs lower Aβ42 and change presenilin 1 conformation
Top Cited Papers
- 26 September 2004
- journal article
- research article
- Published by Springer Nature in Nature Medicine
- Vol. 10 (10) , 1065-1066
- https://doi.org/10.1038/nm1112
Abstract
Recent reports suggest that some commonly used nonsteroidal anti-inflammatory drugs (NSAIDs) unexpectedly shift the cleavage products of amyloid precursor protein (APP) to shorter, less fibrillogenic forms, although the underlying mechanism remains unknown. We now demonstrate, using a fluorescence resonance energy transfer method, that Aβ42-lowering NSAIDs specifically affect the proximity between APP and presenilin 1 and alter presenilin 1 conformation both in vitro and in vivo, suggesting a novel allosteric mechanism of action.Keywords
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