The effects of age on carbamazepine pharmacokinetics and adverse effects.
- 1 December 1986
- journal article
- research article
- Published by Wiley in British Journal of Clinical Pharmacology
- Vol. 22 (6) , 725-728
- https://doi.org/10.1111/j.1365-2125.1986.tb02965.x
Abstract
The pharmacokinetics and effect of single oral doses of carbamazepine (400 mg) were compared in a group of six young volunteers aged between 20 and 25 years, and a second group of five elderly volunteers aged between 66 and 84 years. No age related changes in salivary or plasma pharmacokinetics or in psychomotor function were detected.This publication has 9 references indexed in Scilit:
- Value of saliva samples in monitoring carbamazepine concentrations in epileptic patientsActa Neurologica Scandinavica, 2009
- Drug Disposition in the Elderly: A Review of the Critical FactorsJournal of the American Geriatrics Society, 1984
- Saliva carbamazepine levels in children before and during multiple dosing.Published by Wiley ,1982
- Salivary concentrations and plasma protein binding of carbamazepine and carbamazepine 10,11‐epoxide in epileptic patients.British Journal of Clinical Pharmacology, 1981
- Concentrations and kinetics of carbamazepine in whole saliva, parotid saliva, serum ultrafiltrate, and serumClinical Pharmacology & Therapeutics, 1980
- Psychomotor function and psychoactive drugs.British Journal of Clinical Pharmacology, 1980
- Measurement of carbamazepine and its epoxide metabolite by high-performance liquid chromatography, and a comparison of assay techniques for the analysis of carbamazepine.Clinical Chemistry, 1977
- Distribution and elimination kinetics of carbamazepine in manEuropean Journal of Clinical Pharmacology, 1975