T‐, B‐ and Fc‐γ‐receptor‐bearing lymphocytes in asthma

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Abstract
T [thymus-derived], B [bone marrow-derived] and Fc-.gamma.-receptor-bearing lymphocytes were detected using 6 different membrane markers in patients suffering from asthma having normal or low serum Ig[immunoglobulin]A levels. E [erythrocyte] rosettes aE [active E] rosettes and a human anti-T lymphocyte antiserum (HTLA) were used for T cell determination. In patients with low serum IgA levels E rosettes were significantly decreased. B lymphocytes were identified by EAC [EA-complement] rosette formation and visualization of surface membrane Ig (SmIg). No significant difference was seen. Fc-.gamma.-receptor-bearing lymphocytes were assessed by the EA rosette assay and were significantly decreased in asthmatics with normal IgA levels. This result might be explained by the presence of immune complexes.

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