Kinetics of protolytic and keto–enol reactions of some 5-monosubstituted barbituric acids
- 1 January 1975
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 2
- No. 8,p. 819-821
- https://doi.org/10.1039/p29750000819
Abstract
We have determined the relaxation times in the millisecond range of barbituric acids with the 5-substituents H, methyl, ethyl, isopropyl, and phenyl in aqueous solution as a function of temperature. The kinetic parameters of protolysis and keto–enol interconversion have been evaluated. The influence of the substituents on these parameters can be explained more satisfactorily by the influence of the structure of solvent water rather than by the inductive effect.Keywords
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