Predictive Markers of AIDS Dementia Complex: CD4 Cell Count and Cerebrospinal Fluid Concentrations of 2-Microglobulin and Neopterin

Open Access

1 August 1996

journal article
research article
Published by Oxford University Press (OUP) in The Journal of Infectious Diseases

Vol. 174 (2) , 294-298
https://doi.org/10.1093/infdis/174.2.294

Abstract

A predictive marker for AIDS dementia complex (ADC) in a cohort of neurologically asymptomatic human immunodeficiency virus type 1 (HIV-l)-infected patients with 5 mg/L carrying ∼ 17 times the risk of ADC. CSF β₂M and neopterin levels and CD4 cell count are useful in identifying patients at risk of ADC and as such can be used to target high-risk patients so therapy can be optimized.

Keywords

AIDS DEMENTIA COMPLEX
CD4 COUNT DETERMINATION PROCEDURE
NEOPTERIN
CEREBROSPINAL FLUID
PREDICTIVE MARKER
UNIVARIATE ANALYSIS
T-LYMPHOCYTE SUBSETS
CD4 POSITIVE T-LYMPHOCYTES
FOLLOW-UP
HIV-1
HIV

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