The Ineffectiveness of Steroid Therapy in Treating Aspiration of Hydrochloric Acid
- 1 June 1974
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Surgery
- Vol. 108 (6) , 858-861
- https://doi.org/10.1001/archsurg.1974.01350300090021
Abstract
Following aspiration of 0.1N hydrochloric acid with pH 1.0, 20 mongrel dogs were ventilated mechanically for four hours. Positive end-expiratory pressure of 10 cm H2O was added continuous positive-pressure ventilation (CPPV). In addition to CPPV, ten of the dogs received methylprednisolone (30 mg/kg body weight). The CPPV improved arterial oxygen tension, decreased venous admixture, increased arterial-venous oxygen content difference, and decreased systemic blood pressure. The addition of methyl-prednisolone did not significantly improve oxygenation, survival, or any other variable measured.This publication has 1 reference indexed in Scilit:
- Aspiration pneumonia: Pulmonary arteriography after experimental aspirationJournal of Surgical Research, 1972