Renal Clearance of Pantothenic Acid in Man: Inhibition by Probenecid ('Benemid').
- 1 April 1953
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 82 (4) , 604-608
- https://doi.org/10.3181/00379727-82-20191
Abstract
At plasma levels of 30 to 50 [MU]g./cc., significant renal tubular secretion of pantothenic acid occurs. It is probable that pantothenic acid is secreted by the same renal tubular transport mechanism involved in the transport of penicillin, phenol-sulfonphthalein and PAH. Probenecid can inhibit effectively the renal tubular secretion of pantothenic acid in man. Probenecid enhances the plasma pantothenate levels obtained by the intraven. administration of Na pantothenate in doses of 500 and 1000 mg.Keywords
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