Levodopa Relief of Bone Pain from Breast Cancer

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Abstract
To the Editor: Prolactin has been implicated by Stoll and others as the major hormonal stimulant to breast-cancer development.1 Two recent papers by Malarkey,2 and Kleinberg3 and their associates on L-dopa suppression of prolactin in human beings, led to its use in six patients with advanced breast cancer. No clinical response was seen in four patients who had previously proved to have endocrine-insensitive cancer as demonstrated by no remission of bone pain following oophorectomy or hormonal therapy. Two patients with apparent endocrine-sensitive tumors responded.One of them, 37 years old, had painful bony metastasis 24 months before admission after subtotal . . .

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