Reversal of central anticholinergic syndrome by galanthamine
- 21 November 1977
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA
- Vol. 238 (21) , 2293-2294
- https://doi.org/10.1001/jama.238.21.2293
Abstract
Volunteers (10) were given 2 mg scopolamine i.v. to produce substantial drowsiness and sleepiness. Galanthamine [from Galanthus nivalis], 0.5 mg/kg i.v., effectively reversed the central anticholinergic syndrome produced by scopolamine. EEG monitoring of 2 subjects confirmed the observed changes of consciousness: scopolamine replaced the dominant awake .alpha. rhythm with a disorganized, slow, 4-6 Hz activity. Galanthamine promptly returned the EEG pattern to the control, awake state. Galanthamine produces effective, safe and long-lasting reversal of the central anticholinergic syndrome in man.This publication has 1 reference indexed in Scilit: