Mithramycin in the Treatment of Disseminated Testicular Neoplasms

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Abstract
DISSEMINATED testicular neoplasms other than seminoma have not been effectively controlled by radiologic therapy or chemotherapeutic agents. In an evaluation of these tumors Whitmore1 stated that chemotherapy had no practical value in most cases because of the brevity or incompleteness of the remissions obtained. There were only 5 effective remissions in 100 treated patients. A recently introduced antibiotic, mithramycin, has demonstrated striking antitumor activity in testicular neoplasms, especially the embryonal-cell carcinoma.Except for seminoma, there is a consistently poor prognosis for testicular neoplasms of germinal origin. Dixon and Moore2 reviewed 990 testicular tumors in the United States Army population from . . .