The chemotherapy of Eperythrozoon coccoides (Schilling, 1928)

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Abstract
In tests for chemotherapeutic activity, mice were infected with Eperythrozoon coccoides, treated with drugs for 2 days, splenectomized, and treated with drugs for a further 2 days. Blood films were examined from the second day after splenectomy, when control mice showed heavy blood infections.Neoarsphenamine, aureomycin and terramycin were active.Tryparsamide, Chloromycetin, alloxan and polyoxyethylene ether, D2, were slightly active.Many drugs, listed in Table 3, were inactive.Neoarsphenamine cleared E. coccoides from the blood very rapidly. This action was inhibited by dimercaprol (BAL).E. coccoides closely resembles Haemobartonella muris in its sensitivity to drugs. Both micro-organisms probably have affinities with the Rickettsiae.