RESPONSES OF THE DOMESTIC FOWL TO HYPER- AND HYPOGLYCEMIC AGENTS

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Abstract
RECENTLY, increasing attention has been paid to the effects of various hyper- and hypoglycemic agents in studies of mammalian carbohydrate metabolism. Both cobaltous chloride (1) and Synthalin A (2) have been used to damage the pancreatic alpha cells in efforts to study the role which glucagon-release might play in the carbohydrate scheme; l-tryptophan (3) and certain sulfonylureas (4, 5) have been studied for their bloodsugar-lowering effects. Little work has been done on responses of the fowl to either anti-insulin or insulin-like substances. Yet responses of mammals to these substances prompt the study of them in animals, such as the fowl, whose normal bloodglucose level is quite high compared with that of mammals, but which are in themselves unresponsive to diabetogenic techniques. Herein are reported experiments with two of these substances, cobaltous chloride and 1-butyl-3-p-tolysulfonylurea (Orinase1), on carbohydrate metabolism in the domestic fowl. Some experimental responses of chickens of different ages to exogenous glucagon2 are also reported.

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